Which factor increases a patient's risk of developing an aspirin-induced ulcer?

Cigarette smoking significantly increases a patient's risk of developing an aspirin-induced ulcer due to its impact on gastric mucosal defense mechanisms. Smoking is known to impair the production of bicarbonate and mucus in the stomach, which are crucial for maintaining the protective barrier. Without these protective factors, the gastric lining becomes more susceptible to the harmful effects of acid and irritants such as aspirin.

Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), can lead to gastrointestinal mucosal injury and ulceration, especially in individuals who are already at risk. The combination of smoking and the irritative effect of aspirin on the stomach lining creates a heightened likelihood of ulcer development.

While other factors such as excessive exercise, a high-fat diet, or low water intake can influence overall health or digestive function, they do not have the same direct correlation with altering gastric defenses and increasing ulcer risk in relation to aspirin use as smoking does. Thus, smoking is the key factor in this scenario, making it the correct response regarding increased ulcer risk associated with aspirin.