VATI Pharmacology Practice Exam

Sumatriptan is a medication specifically designed to treat certain types of headaches, particularly migraines and cluster headaches, by acting on serotonin receptors to cause vasoconstriction of cerebral blood vessels. However, it is contraindicated in patients with a history of cardiovascular conditions, such as angina pectoris. This is because sumatriptan can narrow blood vessels, which may exacerbate conditions like angina that are characterized by insufficient blood flow to the heart.

Using sumatriptan in patients with angina pectoris poses a risk of worsening cardiac issues, as the medication can potentially lead to increased workload on the heart and further ischemia in those already compromised by coronary artery disease. Essentially, the vasoconstrictive properties of sumatriptan can lead to serious cardiovascular events in susceptible individuals.

In contrast, severe migraines, tension headaches, and cluster headaches are indications for the use of sumatriptan, as those conditions benefit from its effects in relieving headache symptoms. Thus, the presence of angina pectoris serves as a strong contraindication for the use of this medication.