When should diclofenac sodium be administered to minimize gastric irritation?

Diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), can cause gastric irritation as a side effect. To minimize this risk, it is recommended to administer the medication with food. Taking diclofenac with food helps buffer the acidity in the stomach and decreases the likelihood of gastrointestinal discomfort or irritation. This is particularly important for patients who may be prone to gastric issues or who require long-term use of NSAIDs, as they can potentially lead to gastritis or ulcers. By taking the medication alongside food, the absorption is not significantly altered while providing a protective effect on the gastric mucosa.