When administering acyclovir, what should the nurse assess for regarding kidney function?

When administering acyclovir, it is essential for the nurse to assess for increased creatinine levels as an indicator of kidney function. Acyclovir is primarily excreted through the kidneys, and its use can lead to nephrotoxicity, particularly at high doses or in patients with preexisting kidney impairment. When acyclovir accumulates, it can cause damage to kidney tubules, leading to elevated serum creatinine levels, which is a standard measure of renal function. Monitoring creatinine helps the nurse detect any potential renal complications early, allowing for timely interventions, such as dose adjustments or hydration to help protect kidney function during treatment.

While decreased urine output, electrolyte imbalances, and urinary frequency can also be relevant assessments in the context of kidney health and overall patient condition, the specific and direct link between acyclovir administration and increased creatinine levels makes this the most critical parameter to monitor for renal function assessment in this scenario.