What is the therapeutic range for Digoxin?

The therapeutic range for Digoxin is established based on its effectiveness in treating conditions such as heart failure and certain types of arrhythmias, as well as its potential toxicity. The range of 0.5 to 2 ng/mL reflects the optimal serum levels required to achieve therapeutic effects while minimizing the risk of adverse reactions.

In this range, Digoxin can enhance cardiac output and regulate heart rhythms effectively. Levels below 0.5 ng/mL may be insufficient to control symptoms of heart failure or arrhythmias, while levels above 2 ng/mL increase the likelihood of toxicity. Symptoms of Digoxin toxicity can include nausea, vomiting, confusion, and cardiac disturbances, making it crucial to maintain serum levels within the therapeutic range for patient safety and drug efficacy.

The specified range emphasizes the importance of careful monitoring and adjustment of doses to achieve the desired outcomes while avoiding complications associated with both under-treatment and overdose.