What is a common side effect of Tamoxifen that could affect a patient’s quality of life?

Tamoxifen is a medication primarily used in the treatment and prevention of hormone receptor-positive breast cancer. A common side effect associated with Tamoxifen is hot flashes, which can significantly impact a patient's quality of life.

Hot flashes occur due to Tamoxifen's influence on estrogen receptors in the body, mimicking some of the hormonal changes experienced during menopause. Patients may report sudden feelings of warmth, sweating, and discomfort, particularly during the night or in warmer environments, which can lead to sleep disturbances and increased discomfort during daily activities.

While night sweats, dry skin, and frequent headaches can also occur with Tamoxifen or other medications, hot flashes are particularly prevalent and characteristically linked to hormonal treatments like Tamoxifen. Understanding this side effect is crucial for healthcare providers when counseling patients about what to expect during treatment and how to manage these symptoms effectively.